| CatalogCode: | NB120-3446 |
| ProductName: | NFAT 5 Antibody |
| Product Description: | Rabbit Polyclonal anti-NFAT 5 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide: CD(1439)LLVSLQNQGNNLTGSF(1455).Immunizing peptide corresponds to the C-terminal 17 amino acid residues of human NFAT 5. This sequence is 94% conserved in the mouse protein. |
| Specificity: | Detects Nuclear Factor of Activated T-cells 5 (NFAT 5). |
| CrossReactivity: | Cross-reacts with Human.Expected to cross-react with Mouse due to sequence homology.Not yet tested in other species. |
| Packaging: | 0.05 mg Immunogen affinity purified Rabbit IgG. |
| Uses: | Immunocytochemistry: use at a dilution of 1/1000. Western Blot: use at a dilution of 1/2000.Not tested in other applications.Optimal dilutions / concentrations should be determined by the end user.By Western blot, this antibody detects an ~170 kDa protein representing NFAT 5 in HEK293 cells transfected with the human NFAT 5 gene.Immunocytochemical staining of NFAT 5 in HEK293 cells transfected with the human NFAT5 gene results in primarily cytoplasmic staining. |
| Background: | The nuclear factor of activated T-cells (NFAT) transcription complex is required for the expression of a group of proteins that collectively regulate the immune response. Four NFAT proteins, encoded on separate genes and expressed as several splice variants, have been described: NFAT1 (also known as NFATp or NFATc2), NFAT2 (NFATc or NFATc1), NFAT3, and NFAT4 (NFATx or NFATc3). These proteins show a low level of sequence similarity with the Dorsal/Rel/NFkB family of transcription factors. Another NFAT-related protein termed NFAT5 differs from isoforms 1-4 in that it lacks many of the Fos/Jun contact sites observed in its predecessors and its subcellular localization is not calcineurin-dependent. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS |
| ListPrice: | 285 |
| AppSummary: | WB, ICC, GS, ICC |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Glutamine rich protein H65 antibody, anti-KIAA0827 antibody, anti-NF AT5 antibody, anti-NFAT 5 antibody, anti-NFAT L1 antibody, anti-NFAT like protein 1 antibody, anti-NFATL 1 antibody,anti-NFATL1 antibody ,anti-NFATZ antibody , anti-Nuclear factor of activated T cells 5 antibody, anti-Nuclear factor of activated T cells 5 tonicity responsive antibody, anti-Nuclear factor of activated T cells antibody, anti-OREBP antibody, anti-Osmotic response element binding protein antibody, anti-T cell transcription factor NFAT 5 antibody, anti-T cell transcription factor NFAT5 antibody, anti-TonE binding protein antibody, anti-TONEBP antibody, anti-Tonicity responsive enhancer binding protein antibody |
| ProteinTarget: | NFAT 5 |
| PackageSize: | 0.05 mg |
| GeneralRef: | General / background references:Shen K & Meyer T Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation. Science 284:162-6 (1999). |
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