| CatalogCode: | NB120-3440 |
| ProductName: | Serotonin N-acetyltransferase Antibody |
| Product Description: | Rabbit Polyclonal anti-Serotonin N-acetyltransferase [Ser206] |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide: C(198)HTFLRRNS(p)GC(208).Immunizing phosphopeptide corresponds to C-terminal amino acid residues 198-208 of rat AA-NAT. This sequence is completely conserved between rat and mouse AA-NAT protein. |
| Specificity: | This antibody detects phospho serotonin N-acetyltransferase (AA-NAT) from rat tissues. |
| CrossReactivity: | Cross-reacts with Rat. Expected to cross-react with Mouse due to sequence homology. |
| Packaging: | 0.5 mg Liquid. |
| Uses: | Western Blot: use at a concentration of 0.5 ug/ml. By Western blot, this antibody detects an ~23 kDa protein representing phosphorylated AA-NAT from rat pineal gland whole protein extract. |
| Background: | Pineal gland Serotonin N-acetyltransferase (Arylalkylamine N-acetyltransferase, AA-NAT) is a ~23 kDa protein which is the rate-limiting enzyme in melatonin synthesis. Melatonin serves as the hormonal signal of the daily light / dark cycle, or body clock. The nocturnal oscillation in enzyme activity ranges by 10- to 100-fold depending on species among vertebrates. Studies have shown that AA-NAT is regulated by cAMP at both the mRNA and protein levels. AA-NAT has putative protein kinase A (PKA) sites at Thr 29 and Ser 206. Phosphorylation of AA-NAT at these residues might play a role in protein inactivation via proteasome-dependent degradation. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS, 1 mg/ml BSA |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Rt |
| ProteinTarget: | Serotonin N-acetyltransferase |
| PackageSize: | 0.05 mg |
| GeneralRef: | General / background references:Li X et al. Molecular rhythms in the pineal gland. Curr Opin Neurobiol 8:648-51 (1998). |
| Phosphorylated: | Ser206 |