| CatalogCode: | NB120-3377 |
| ProductName: | MRP 5 Antibody |
| Product Description: | Rat Monoclonal anti-MRP 5 (M5I-1) |
| Clone: | M5I-1 |
| Clonality: | Monoclonal |
| Immunogen: | Bacterial fusion protein of human MRP 5 containing amino acids 82-168. |
| Epitope: | Internal epitope. |
| Specificity: | Human multidrug-resistance protein (MRP) gene family is composed of multiple members such as: MRP1, MRP2 or cMOAT, and four other homologous genes, called MRP3, MRP4, MRP5 and MRP6. Within the MRP family, MRP5 is closely related to MRP4. Both MRP4 and MRP5 lack the first five membrane-spanning regions.Signet clone M5I-1 reacts with an internal epitope of the transmembrane protein MRP5 (190-200 kDa). Clone M5I-1 does not cross-react with MDR1, MRP1, MRP2 or MRP3 gene products.This antibody was developed against a bacterial fusion protein of MRP5 containing the segment of 82-168 AA. |
| CrossReactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.25 ml Rat Tissue culture supernatant |
| Uses: | Optimal dilutions / concentrations should be determined by the end user. |
| Background: | MRP5 (190-200 kDa) is closely related to MRP4, both lacking the first five membrane spanning regions. MRP5 is a GS-X multi specific organic anion pump (nucleotide analogs). MRP5 may transport DNP-GS and may be inhibited by certain inhibitors of organic anion transport (sulfinpyrazone). MRP5 may also transport organic anions with the anionic moiety of phosphate/phosphonate group, a function which provides the ability to resist against anti cancer drugs 6-MP and thioguanine as well as the anti-HIV drug PMEA. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Tissue culture supernatant |
| Isotype: | IgG |
| Host_Name: | Rat |
| Buffer: | PBS |
| ListPrice: | 285 |
| AppSummary: | ICC, IHC-Fr, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-ABC 33 antibody, anti-ABC33 antibody, anti-ABCC 5 antibody, anti-ABCC5 antibody, anti-ATP binding cassette sub family C (CFTR/MRP) member 5 antibody, anti-ATP binding cassette sub family C member 5 antibody, anti-Canalicular multispecific organic anion transporter C antibody, anti-DKFZp686C1782 antibody, anti-EST277145 antibody, anti-MOAT C antibody, anti-MOATC antibody, anti-MRP 5 antibody, anti-Multi specific organic anion tranporter C antibody, anti-Multidrug resistance associated protein 5 antibody, anti-pABC 11 antibody, anti-pABC11 antibody, anti-SMRP antibody |
| ProteinTarget: | MRP 5 |
| PackageSize: | 0.25 ml |
| GeneralRef: | Scheffer GL, et al. Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies. Cancer Res 60(18):5269-77, 2000. (WB) Wijnholds J, et al. Multidrug resistance protein 5 is a multimeric organic anion transporter able to transport nucleotide analogos. Proc Natl Acad Sci USA 97:7476-81, 2000. Kool M, et al. Analysis of expression of cMOAT (MRP2), MRP3, MRP4 and MRP5 homologs of the multidrug resistance-associated protein gene (MRP1) in human cancer cell lines. Cancer Res 57:3537-3547, 1997. |
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