| request information: |
|
| Catalog Code: | NB120-3344 |
| Product Name: | SYNGAP Antibody |
| Product Description: | Rabbit Polyclonal anti-SYNGAP |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Fusion protein of a recombinant fragment, amino acids 947-1167, of rat SynGAP. |
| Specificity: | This antibody detects synaptic Ras-GTPase activating protein (SynGAP) from mouse and rat tissues. |
| Cross Reactivity: | Cross-reacts with Rat and Mouse.Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | Immunocytochemistry: use at a concentration of 1 ug/ml.Western Blot: use at a concentration of 1 ug/ml.Not tested in other applications.Optimal dilutions / concentrations should be determined by the end user.By Western blot, this antibody detects an ~135 kDa protein representing SynGAP from mouse brain tissue homogenate. Immunocytochemical staining of SynGAP in rat hippocampal neurons yields a pattern consistent with vesicular staining. |
| Background: | Synaptic Ras GTPase Activating Protein (SynGAP) is a PDZ-domain interacting protein expressed almost exclusively in the brain. SynGAP has been shown to be a major component of postsynaptic density and associates with post synaptic density 95 kDa (PSD-95), a synaptic scaffold protein, and synaptic N-methyl-D-aspartate (NMDA) receptors. SynGAP Ras-GTPase activity has also been shown to be inhibited by phosphorylation by CaM kinase II, another abundant protein located in the postsynaptic density. It has been proposed that SynGAP may function as a negative regulator of MAP Kinase activation in the absence of active NMDA receptors. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | PBS, 1 mg/ml BSA |
| Application Summary: | Western Blot 1 ug/mL, Immunocytochemistry 1 ug/mL |
| Species Summary: | Mu, Rt, |
| Alternate Names: | antiDKFZp761G1421 antibody, antiKIAA1938 antibody, antiNeuronal RasGAP antibody, anti-OTTHUMP00000064825 antibody, antip135 SynGAP antibody, antiRas GTPase activating protein SynGAP antibody, antiRASA 1 antibody, antiRASA 5 antibody, antiRASA1 antibody, antiRASA5 antibody, antiSantiynaptic Ras GAP 1 antibody, antiSynaptic Ras GTPase activating protein 1 antibody, antiSynaptic Ras GTPase activating protein 1 homolog antibody, antiSynaptic Ras GTPase activating protein 135kDa antibody, antisynaptic Ras GTPase activating protein antibody, antiSYNGAP 1 antibody, antiSYNGAP1 antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.05% sodium azide |
| General References: | General / background references:Kim JH et al. SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family. Neuron 20:683-91 (1998). Chen HJ et al. A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II. Neuron 20:895-904 (1998). |
order or
more information: | company product webpage |