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| Catalog Code: | NB120-3334 |
| Product Name: | Proteasome Activator 11S REG Gamma Antibody |
| Product Description: | Rabbit Polyclonal anti-Proteasome Activator 11S REG Gamma |
| Clonality: | Polyclonal |
| ListPrice: | 285 |
| Immunogen: | Synthetic peptide: MASLLKVDQEVKLK-C, corresponding to amino acids 1-14 of Human Proteasome Activator 11S REG gamma. |
| Specificity: | Detects recombinant human proteasome activator 11S REG gamma subunit. |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Rabbit IgG. |
| Uses: | Western Blot: use at 1 ug/ml.By Western blot, this antibody detects a 28 kDa protein representing recombinant human 11S REG gamma. |
| Background: | Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome, and Liddle syndrome. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | PBS |
| Application Summary: | Western Blot 1 µg/ml |
| Species Summary: | Hu |
| Alternate Names: | anti-PSME3 antibody, anti-11S regulator complex gamma subunit antibody, anti-Activator of multicatalytic protease subunit 3 antibody, anti-Ki antibody, anti-Ki antigen antibody, anti-Ki nuclear autoantigen antibody, anti-Ki, PA28 gamma antibody, anti-PA28 gamma antibody, anti-PA28G antibody, anti-Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) antibody, anti-Proteasome (prosome, macropain) activator subunit 3 antibody, anti-Proteasome activator 28 gamma antibody, anti-Proteasome activator subunit 3 antibody, anti-REG GAMMA antibody |
| Package Size: | 0.1 mg |
| Preservative: | 1 mg/ml BSA |
| General References: | General / background references:Voges D et al. The 26S proteasome: a molecular machine designed for controlled proteolysis. Annu Rev Biochem 68:1015-68 (1999). Schwartz AL & Ciechanover A The ubiquitin-proteasome pathway and pathogenesis of human diseases. Annu Rev Med 50:57-74 (1999). |
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