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| Catalog Code: | NB120-3219 |
| Product Name: | SMAD 4 Antibody |
| Product Description: | Mouse Monoclonal anti-SMAD 4 (SMD46 (same as DCS-46)) |
| Clone: | SMD46 (same as DCS-46) |
| Clonality: | Monoclonal |
| ListPrice: | 335 |
| Concentration: | 0.2 mg/ml |
| Immunogen: | Purified recombinant DPC4 protein. |
| Cross Reactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.5 ml Affinity purified Mouse ascites. |
| Uses: | Western Blotting: use for 2hrs at RT. By Western blot, this antibody detects a band of 60 kDa, which corresponds to the predicted molecular weight of SMAD 4. |
| Localization: | Nuclear. |
| Background: | Smad4 is a common mediator of signal transduction by the TGF-beta (transforming growth factor) superfamily; it may act as a tumor suppressor. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Affinity purified |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Buffer: | 10mM PBS, pH7.4, 0.2%BSA |
| Application Summary: | chromatin immunoprecipitation , immunofluorescence , immunoprecipitation 2ug/mg, Western Blot 1-2ug/ml |
| Species Summary: | Hu, |
| Alternate Names: | Anti-(Small) Mothers Against Decapentaplegic antibody, Anti-Deleted in Pancreatic Carcinoma antibody, Anti-Deleted in pancreatic carcinoma locus 4 antibody, Anti-Deletion target in pancreatic carcinoma 4 antibody, Anti-DPC 4 antibody, Anti-DPC4 antibody, Anti-hSMAD4 antibody, Anti-JIP antibody, Anti-MAD homolog 4 antibody, Anti-MAD mothers against decapentaplegic homolog 4 antibody, Anti-MADH 4 antibody, Anti-MADH4 antibody, Anti-Mothers against decapentaplegic homolog 4 antibody, Anti-Mothers against DPP homolog 4 antibody, Anti-Smad 4 antibody, Anti-SMAD family member 4 antibody, Anti-SMAD mothers against DPP homolog 4 antibody |
| Package Size: | 0.5 ml |
| Preservative: | 0.09% sodium azide |
| General References: | This product has been used in:Furukawa F et al. p38 MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblasts. Hepatology 38:879-89 (2003). General / background references:Jonson T et al. Molecular analyses of the 15q and 18q SMAD genes in pancreatic cancer. Genes Chromosomes Cancer 24:62-71 (1999). Mangray S & King TC Molecular pathobiology of pancreatic adenocarcinoma. Front Biosci 3:D1148-60 (1998). |
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