| CatalogCode: | NB120-3161 |
| ProductName: | TIMP2 Antibody |
| Product Description: | Mouse Monoclonal anti-TIMP2 (T2-101) |
| Clone: | T2-101 |
| Clonality: | Monoclonal |
| Immunogen: | Native human pro-MMP-2/TIMP-2 complex purified from A2058 culture medium. |
| Epitope: | aa 111-126. This epitope is not involved in binding of TIMP-2 to MMP-2. |
| CrossReactivity: | Cross-reacts with Human.Does not cross-react with Rat or Mouse.Not yet tested in other species. |
| Packaging: | 0.5 ml Mouse ascites. |
| Uses: | Immunoprecipitation: use at a concentration of 2ug / mg.Western Blotting: use at a concentration of 1 - 2ug/ml for 2hrs at RT.Not tested in other applications.Optimal dilutions / concentrations should be determined by the end user.By Western blot, this antibody detects a band of 21 kDa, which corresponds to the predicted molecular weight of TIMP-2. |
| Localization: | Secreted |
| Control: | Conditioned, serum-free medium from (TPA-treated) human fetal lung cell line HFL-1. |
| Storage: | Store at 4C. Do not freeze. |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | 10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide |
| ListPrice: | 330 |
| AppSummary: | IP, WB |
| SpeciesSummary: | Hu, Rt (-), Mu (-) |
| ProteinTarget: | TIMP 2 |
| PackageSize: | 0.5 ml |
| GeneralRef: | General / background references:Hurskainen T et al. mRNA expressions of TIMP-1, -2, and -3 and 92-KD type IV collagenase in early human placenta and decidual membrane as studied by in situ hybridization. J Histochem Cytochem 44:1379-88 (1996). Hurskainen T et al. Expression of the tissue metalloproteinase inhibitors TIMP-1 and TIMP-2 in malignant fibrous histiocytomas and dermatofibromas as studied by in situ hybridization and immunohistochemistry. Hum Pathol 27:42-9 (1996). Hoyhtya M et al. Immunohistochemical localization of matrix metalloproteinase 2 and its specific inhibitor TIMP-2 in neoplastic tissues with monoclonal antibodies. Int J Cancer 56:500-5 (1994). Visscher DW et al. Enhanced expression of tissue inhibitor of metalloproteinase-2 (TIMP-2) in the stroma of breast carcinomas correlates with tumor recurrence. Int J Cancer 59:339-44 (1994). |
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