| Catalog Code: | NB120-3132 |
| Product Type: | Primary Antibody |
| Product Name: | PI 3 Kinase Antibody |
| List Price: | 330 |
| Clonality: | Monoclonal |
| Gene ID: | 5294 |
| Host: | Mouse |
| Clone: | 8-2D-4D |
| Isotype: | IgG1 |
| Product Description: | Mouse Monoclonal anti-PI 3 Kinase (8-2D-4D) |
| Cross Reactivity: | Cross-reacts with Human, Rat and Mouse.Not yet tested in other species. |
| Species Summary: | Hu, Rt, Mu |
| Background: | The enzyme PI-3-K phosphorylates at the D-3 position of the inositol ring of PI, PI-4- phosphate and PI-4,5-biphosphate (PI-4,5-P2) to produce their respective PI3-phosphorylated derivatives. PI-3-K exists as a heterodimer of 85 kDa (p85) and 110 kDa (p11 |
| Immunogen: | Purified fragment (aa 333 - 430) of recombinant human PI-3-K p85 alpha subunit. |
| Localization: | Cytoplasmic |
| Purity: | Protein G purified |
| Buffer: | 10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide |
| Packaging: | 500 microlitres Liquid. |
| Package Size: | 0.5 ml |
| Uses: | Not tested in applications other than those listed above.Optimal dilutions / concentrations should be determined by the end user.By Western blot, this antibody detects a band of ~ 85 kDa, which corresponds to the predicted molecular weight of PI 3 Kinase. |
| Application Summary: | IF, WB |
| General References: | General / background references:Ward SG et al. PI 3-kinase: a pivotal pathway in T-cell activation? Immunol Today 17:187-97 (1996). Weber G et al. Current issues in the regulation of signal transduction. Adv Enzyme Regul 36:33-55 (1996). < |
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