| CatalogCode: | NB120-2950 |
| ProductName: | Cyclin C Antibody |
| Product Description: | Rabbit Polyclonal anti-Cyclin C |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide: C-QGPNGSQNSSYSQS, corresponding to amino acids 290-303 of Human Cyclin C. |
| CrossReactivity: | Cross-reacts with Human, Rat, Mouse and Dog. Not yet tested in other species. |
| Packaging: | 0.5 ml protein A purified Rabbit antisera. |
| Uses: | Immunoprecipitation: (co-precipitates cdk8). WB: 2 Hrs at Rt |
| Localization: | Nuclear |
| Background: | Cyclin C was originally identified by a genetic screen for human and Drosophila cDNAs that complement a triple knock-out of the CLN genes in Saccharomyces cerevisiae. Cyclin C is a nuclear protein present in a multiprotein complex. It interacts both in vitro and in vivo with cdk8, a novel protein-kinase of the cdk family. It is suggested that cyclin C and cdk8 control RNA polymerase II function. Human cdk8-cyclin C might be functionally associated with the mammalian transcription apparatus, perhaps involved in relaying growth-regulatory signals. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | protein A purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 10mM PBS, pH7.4, 0.2%BSA |
| ListPrice: | 295 |
| AppSummary: | IP, WB |
| SpeciesSummary: | Ca, Hu, Mu, Rt |
| ProteinTarget: | Cyclin C |
| PackageSize: | 0.5 ml |
| GeneralRef: | 1. Li H; Lahti JM; Kidd VJ. Oncogene, 1996 Aug 15, 13(4):705-12. 2. Yaglom JA; et al. Molecular and Cellular Biology, 1996 Jul, 16(7):3679-84. 3. Demetrick DJ; et al. Cytogenetics and Cell Genetics, 1995, 69(3-4):190-2. 4. Rickert P; et al. Oncogene, 1996 Jun 20, 12(12):2631-40. 5. Tassan JP; et al Proc Natl Acad Sci USA 1995, 92(19):8871-5. 6. Leclerc V; et al. Molecular Biology of the Cell, 1996, 7:505-13. |
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