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| Catalog Code: | NB120-2366 |
| Product Name: | Somatostatin Receptor Antibody |
| Product Description: | Rabbit Polyclonal anti-Somatostatin Receptor |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Synthetic peptide (Rat). |
| Specificity: | This antibody reacts with a 60 kD protein, known as Somatostatin. Receptor. |
| Cross Reactivity: | Cross-reacts with Rat and Mouse. Not yet tested in other species. |
| Packaging: | 0.5 ml Rabbit antisera. |
| Uses: | IHC: This antibody may be diluted to a titer of 1:50-1:75 in an ABC method. We suggest an incubation period of 30 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation conditions and antibody dilutions should be determined by the user. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. |
| Localization: | Cytoplasmic |
| Background: | The Somatostatin family of receptors have five members, sst1-sst5, as well as two isoforms of Somatostatin receptor 2, sst2A and sst2B. They are coupled to G protein and are involved in regulation of numerous processes including secretion of insulin, glucagons and growth hormone and excitation of neurons in central and peripheral nervous system. |
| Storage: | Store at 4C. Do not freeze. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | PBS |
| Application Summary: | immunohistochemistry-Fr, immunohistochemistry-P |
| Species Summary: | Mu, Rt, |
| Alternate Names: | anti-G protein coupled receptor antibody, anti-Somatostatin receptor 1 antibody, anti-Somatostatin receptor type 1 antibody, anti-SRIF 2 antibody, anti-SRIF2 antibody, anti-SS 1R antibody, anti-SS R1 antibody, anti-SS1R antibody, anti-SSR 1 antibody, anti-SSR1 antibody, anti-SSTR 1 antibody, anti-SSTR1 antibody |
| Package Size: | 0.5 ml |
| Preservative: | sodium azide |
| General References: | General / background references:Florio T et al. Somatostatin receptor 1 (SSTR1)-mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade: role of the phosphotyrosine phosphatase SHP-2. J Physiol Paris 94:239-50 (2000). Schulz S et al. Localization of five somatostatin receptors in the rat central nervous system using subtype-specific antibodies. J Physiol Paris 94:259-64 (2000). Gu YZ et al. Development and use of a receptor antibody to characterize the interaction between somatostatin receptor subtype 1 and G proteins. Mol Pharmacol 48:1004-14 (1995). |
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more information: | company product webpage |