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| Catalog Code: | NB120-22858 |
| Product Name: | Integrin alpha 4 Antibody |
| Product Description: | Mouse Monoclonal anti-Integrin alpha 4 (HP2/1) |
| Clone: | HP2/1 |
| Clonality: | Monoclonal |
| ListPrice: | 285 |
| Concentration: | 0.2 mg/ml |
| Immunogen: | JM leukaemia line (Human). |
| Specificity: | This antibody recognises the 80kD alpha chain of VLA-4. Reacts with monocytes, T cells, B cells, thymocytes and Langerhans cells. |
| Cross Reactivity: | Cross-reacts with Human, Rat, Cow, Pig and Rhesus monkey. Not yet tested in other species. |
| Packaging: | 0.1 mg Mouse ascites. |
| Uses: | Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Type I membrane protein |
| Background: | Can be used in basic studies of VLA-4 mediated adhesion and its interaction with the VCAM-1 structure. HP2/1 inhibits cell binding to soluble VCAM-1. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Affinity purified |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Buffer: | PBS. pH 7.4 |
| Application Summary: | flow cytometry / FACS analysis , immunoprecipitation , Immunohistochemistry-Frozen |
| Species Summary: | Bv, Hu, Po, Mk, Rt, |
| Alternate Names: | anti-Alpha 4 subunit of VLA 4 receptor antibody, anti-Antigen CD49D antibody, anti-CD 49d antibody, anti-CD49d antibody, anti-CD49d antigen antibody, anti-CDw49d antibody, anti-IA4 antibody, anti-Integrin alpha IV antibody, anti-ITGA 4 antibody, anti-ITGA4 antibody, anti-LPAM23 antibody, anti-MGC90518 antibody, anti-Very Late Activation Antigen 4 antibody, anti-Very Late Activation Protein 4 Receptor Alpha 4 Subunit antibody, anti-VLA 4 antibody, anti-VLA4 antibody |
| Package Size: | 0.1 mg |
| Preservative: | No Preservative |
| General References: | General / background references:Sopper S et al. Lymphocyte subsets and expression of differentiation markers in blood and lymphoid organs of rhesus monkeys. Cytometry 29:351-62 (1997). Mattila P et al. VLA-4 integrin on sarcoma cell lines recognizes endothelial VCAM-1. Differential regulation of the VLA-4 avidity on various sarcoma cell lines. Int J Cancer 52:918-23 (1992). Weller PF et al. Human eosinophil adherence to vascular endothelium mediated by binding to vascular cell adhesion molecule 1 and endothelial leukocyte adhesion molecule 1. Proc Natl Acad Sci U S A 88:7430-3 (1991). Sanchez-Madrid F et al. VLA-3: a novel polypeptide association within the VLA molecular complex: cell distribution and biochemical characterization. Eur J Immunol 16:1343-9 (1986). |
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