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| Catalog Code: | NB120-21307 |
| Product Name: | HtrA2/Omi Antibody |
| Product Description: | Rabbit Polyclonal anti-HtrA2/Omi |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Concentration: | 1 mg/ml |
| Immunogen: | Synthetic peptide (Human). A peptide corresponding to 15 amino acids near the C-terminus of human HtrA2. |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.05 mg ion exchange chromatography purified Rabbit IgG. |
| Uses: | WB: Use at a concentration of 0.5 - 1 ug/ml. Predicted molecular weight: 48 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Mitochondrial, predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase 8 truncated BID/tBID. |
| Background: | The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti apoptotic activity. Recently, a serine protease has been isolated, which is released from the mitochondria upon induction of apoptosis by apoptotic stimuli. This protein called HtrA2/Omi is a mitochondrial protein that binds to IAP. Like Smac/DAIBLO, the mature HtrA2/Omi protein contains a conserved IAP binding motif (AVPS) at its N terminus. The deregulated expression of HtrA2/Omi in the cytoplasm of mammalian cells induces apoptosis indicating that HtrA2/Omi could participate in the mitochondrial apoptotic pathway. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | PBS |
| Application Summary: | Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-High temperature requirement protein a2 antibody, anti-HTRA 2 antibody, anti-HtrA like serine protease antibody, anti-HtrA serine peptidase 2 antibody, anti-Omi stress regulated endoprotease antibody, anti-PARK 13 antibody, anti-PARK13 antibody, anti-Protease serine 25 antibody, anti-PRSS 25 antibody, anti-PRSS25 antibody, anti-Serine protease 25 antibody, anti-Serine protease HTRA2 mitochondrial antibody, anti-Serine protease htra2 mitochondrial precursor antibody, anti-Serine protease omi antibody |
| Package Size: | 0.05 mg |
| Preservative: | 0.02% Sodium Azide |
| General References: | General / background references:Liston P et al. The inhibitors of apoptosis: there is more to life than Bcl2. Oncogene 22:8568-80 (2003). Vaux DL & Silke J Mammalian mitochondrial IAP binding proteins. Biochem Biophys Res Commun 304:499-504 (2003). Suzuki Y et al. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol Cell 8:613-21 (2001). Crook NE et al. An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif. J Virol 67:2168-74 (1993). |
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more information: | company product webpage |