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| Catalog Code: | NB120-2077 |
| Product Name: | BACE Antibody |
| Product Description: | Rabbit Polyclonal anti-BACE |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Synthetic peptide, corresponding to amino acids 485-501 of Human BACE.The peptide sequence differs fromthose of mouse and rat BACE by one amino acid (1). |
| Cross Reactivity: | Cross-reacts with Human, Rat and Mouse.Not yet tested in other species. |
| Packaging: | 0.05 mg IgG purified Rabbit antisera. |
| Uses: | Western blot at 0.5 to 1 ug/ml detects the 70 kD band of BACE. |
| Localization: | Plasma membrane |
| Background: | BACE1 is a protease responsible for the proteolytic processing of the amyloid precursor protein (APP). Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimers disease. This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease termed beta-secretase (BACE), of which there are two isoforms, BACE1 and 2. This enzyme is synthesized as a propeptide that must be modified to the mature and active form by the prohormone convertase furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP and a membrane-bound remnant. This remnant is then processed by another protease termed gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | PBS with 0.02% sodium azide |
| Application Summary: | Western Blot |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-APP beta secretase antibody, anti-Asp 2 antibody, anti-ASP2 antibody, anti-Aspartyl protease 2 antibody, anti-BACE 1 antibody, anti-BACE antibody, anti-Beta secretase 1 antibody, anti-Beta secretase antibody, anti-Beta site amyloid beta A4 precursor protein cleaving enzyme antibody, anti-Beta site amyloid precursor protein cleaving enzyme 1 antibody, anti-Beta site amyloid precursor protein cleaving enzyme antibody, anti-Beta site APP cleaving enzyme 1 antibody, anti-Beta site APP cleaving enzyme antibody, anti-FLJ90568 antibody, anti-HSPC104 antibody, anti-KIAA1149 antibody, anti-Memapsin 2 antibody, anti-Memapsin2 antibody, anti-Membrane associated aspartic protease 2 antibody, anti-Transmembrane aspartic proteinase Asp2 antibody |
| Package Size: | 0.05 mg |
| Notes Main: | Beta-site APP Cleaving Enzyme. |
| General References: | General / background references:Vassar R et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286:735-41 (1999). Hussain I et al. Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol Cell Neurosci 14:419-27 (1999). Yan R et al. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 402:533-7 (1999). Sinha S et al. Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 402:537-40 (1999). |
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