| CatalogCode: | NB120-19893 |
| ProductName: | uPA Antibody |
| Product Description: | Mouse Monoclonal anti-uPA (SPM457) |
| Clone: | SPM457 |
| Clonality: | Monoclonal |
| Immunogen: | Active form of human uPA. |
| CrossReactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Mouse IgG. |
| Uses: | WB: Use at a concentration of 1 - 2 ug/ml for 2 hours at room temperature. Predicted molecular weight: 48 kDa (proform), 35kDa (active) Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cell Membrane, Cytoplasmic and Secreted. |
| Control: | Conditioned, serum free medium from (TPA treated) human fetal lung cell line HFL1. |
| Background: | Urokinase is a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in the Urokinase gene may be associated with late onset Alzheimer disease and also with decreased affinity for fibrin binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg Val bond in plasminogen. The proprotein is cleaved at a Lys Ile bond by plasmin to form a two chain derivative in which a single disulfide bond connects the amino terminal A chain to the catalytically active, carboxy terminal B chain. This two chain derivative is also called HMW uPA (high molecular weight uPA). HMW uPA can be further processed into LMW uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino terminal fragment. LMW uPA is proteolytically active but does not bind to the uPA receptor. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG1 kappa |
| Host_Name: | Mouse |
| Buffer: | BSA, 10mM PBS. pH 7.4 |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-ATF antibody, anti-ATF uPA antibody, anti-EC 3.4.21.73 antibody, anti-Plasminogen activator antibody, anti-Plasminogen activator urinary antibody, anti-Plasminogen activator urokinase antibody, anti-PLAU antibody, anti-u PA antibody, anti-U plasminogen activator antibody, anti-UPA antibody, anti-UPAM antibody, anti-Urinary plasminogen activator antibody, anti-URK antibody, anti-Urokinase plasminogen activator antibody, anti-Urokinase type plasminogen activator antibody, anti-Urokinase type plasminogen activator precursor antibody |
| ProteinTarget: | uPA [SPM457] |
| PackageSize: | 0.1 mg |
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