| CatalogCode: | | NB120-19891 |
| ProductName: | | FADD Antibody |
| Product Description: | | Rabbit Polyclonal anti-FADD |
| Clonality: | | Polyclonal |
| Immunogen: | | Synthetic peptide (Mouse) (Internal sequence). |
| CrossReactivity: | | Cross-reacts with Human and Mouse. Not yet tested in other species. |
| Packaging: | | 0.05 mg protein A purified Rabbit antisera. |
| Uses: | | WB: Use at a concentration of 2.5 - 5 ug/ml for 2 hours at room temperature. Predicted molecular weight: 23 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | | Cytoplasmic |
| Control: | | Jurkat cells. |
| Background: | | FADD (Fas Associated Death Domain) is an apoptosis adapter molecule enabling transduction of the apoptosis signal initiated via the FasL/Fas receptor interaction. The protein contains a C terminal death domain that interacts with the Fas receptor death domain. The N terminus contains a death effectors domain (DED) which recruits caspase to the death inducing signaling complex (DISC) and initiates the apoptotic caspase cascade. Recruitment of Caspase 8 to the Fas receptor results in oligomerization of the Caspase 8 protein, which in turn drives its autoactivation through self-cleavage. Activated Caspase 8 then activates other downstream caspases including Caspase 9, thereby commiting the cell to undergo apoptosis. FADD is implicated in non-apoptotic cellular pathways such as the regulation of cell cycle machinery in T lymphocytes. This is connected to the phosphorylation state of FADD and to the FasL/TRAIL induced transcriptional activation of cfos protooncogene. FADD also interacts with the hepatitis C virus core protein in the HEK 293 cell line. |
| Storage: | | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | | protein A purified |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | Constituents: BSA, 10mM PBS. pH 7.4 |
| ListPrice: | | 295 |
| AppSummary: | | WB |
| SpeciesSummary: | | Hu, Mu |
| ALTnames: | | anti-GIG3 antibody, anti-MGC8528 antibody, anti-MORT1 antibody |
| ProteinTarget: | | FADD |
| PackageSize: | | 0.05 mg |
| more information: | | company product webpage |