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| Catalog Code: | NB120-1872 |
| Product Name: | Caspase 1 Antibody |
| Product Description: | Rabbit Polyclonal anti-Caspase 1 |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Immunogen: | A synthetic peptide from the second quarter of human Caspase 1 protein. |
| Specificity: | This antibody reacts with the 45 kDa protein Caspase 1. |
| Cross Reactivity: | Cross-reacts with Human, Rat and Mouse. Not yet tested in other species. |
| Packaging: | 0.5 ml IgG purified Rabbit antisera. |
| Uses: | IHC: This antibody may be diluted to a titer of 1:25-1:50 in an ABC method. We suggest an incubation period of 30 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation conditions and antibody dilutions should be determined by the user. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with all10 mM citrate buffer, pH 6.0 prior to immunostaining. |
| Localization: | Nuclear, Cell Membrane |
| Background: | Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a2b2 tetramer to form the active enzyme. Caspase 1 is similar to the cell death gene CED3 of C. elegans and regulates multiple proinflammatory cytokines, including Interleukin 1b and interferon-gamma-inducing factor. Caspase 1 plays a role down stream of Caspase 8 which is involved in Fas-mediated apoptosis. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | IgG purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | PBS |
| Application Summary: | Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Western Blot, |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-CASP 1 antibody, anti-CASP1 antibody, anti-Caspase 1 apoptosis related cysteine peptidase antibody, anti-Caspase 1 apoptosis related cysteine protease antibody, anti-Caspase1 antibody, anti-ICE antibody, anti-IL 1 beta converting enzyme antibody, anti-IL 1BC antibody, anti-IL1B convertase antibody, anti-IL1BC antibody, anti-IL1BCE antibody, anti-Interleukin 1 beta convertase antibody, anti-Interleukin 1 beta convertase precursor antibody, anti-Interleukin 1 beta converting enzyme antibody, anti-Interleukin 1B converting enzyme antibody, anti-P45 antibody |
| Package Size: | 0.5 ml |
| Preservative: | sodium azide |
| General References: | General / background references:Enari M et al. Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature 375:78-81 (1995). |
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more information: | company product webpage |
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