| CatalogCode: | | NB120-1838 |
| ProductName: | | XRCC1 Antibody |
| Product Description: | | Mouse Monoclonal anti-XRCC1 (33-2-5) |
| Clone: | | 33-2-5 |
| Clonality: | | Monoclonal |
| Immunogen: | | Recombinant full length protein (Human). |
| Specificity: | | This antibody is specific for XRCC1 (85 kDa). |
| CrossReactivity: | | Cross-reacts with Human and Rat. Not yet tested in other species. |
| Packaging: | | 0.25 ml protein A purified Mouse ascites. |
| Uses: | | IHC-P: Perform enzymatic antigen retrieval before commencing with IHC staining protocol (10 mM citrate buffer, pH 6.0 ). WB: Predicted molecular weight: 85 kDa. |
| Localization: | | Nuclear |
| Control: | | Testis. |
| Background: | | XRCC1 is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. In testis XRCC1 is expressed at high levels. |
| Storage: | | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | | protein A purified |
| Isotype: | | IgG2b |
| Host_Name: | | Mouse |
| Buffer: | | 10mM PBS, pH 7.4 with 0.2% BSA |
| ListPrice: | | 295 |
| AppSummary: | | IHC, ICC |
| SpeciesSummary: | | Hu, Rt |
| ALTnames: | | anti-DNA repair protein XRCC1 antibody, anti-RCC antibody, anti-X ray repair complementing defective repair in chinese hamster antibody, anti-X ray repair complementing defective repair in chinese hamster cells 1 antibody, anti-X ray Repair Complementing Defective Repair in Chinese Hamster Cells antibody, anti-X ray repair cross complementing protein 1 antibody, anti-XRCC 1 antibody |
| ProteinTarget: | | XRCC-1 |
| PackageSize: | | 0.25 ml |
| GeneralRef: | | General / background references:Cappelli E et al. Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair. J Biol Chem 272:23970-5 (1997). Labudova O et al. The transcription of the XRCC1 gene in the heart of radiation-resistant and radiation-sensitive mice after ionizing irradiation. Pediatr Res 41:435-9 (1997). |
| more information: | | company product webpage |