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| Catalog Code: | NB120-18275 |
| Product Name: | IL2 Receptor alpha Antibody |
| Product Description: | Mouse Monoclonal anti-IL2 Receptor alpha (MEM-181), conjugated to FITC |
| Clone: | MEM-181 |
| Clonality: | Monoclonal |
| ListPrice: | 285 |
| Immunogen: | PHA activated peripheral blood leucocytes. (Human). |
| Specificity: | The antibody MEM-181 reacts with CD25 (Interleukin-2 receptor á chain), a 55 kDa type I transmembrane glycoprotein expressed on activated B and T lymphocytes, activated monocytes/macrophages and on CD4+ T lymphocytes (T regulatory cells); it is lost on resting B and T lymphocytes. |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 100 tests protein G purified Mouse IgG. |
| Uses: | FACS: Use at a concentration of 20 ul/100 ul of whole human blood. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Type I membrane protein. |
| Background: | The Interleukin 2 Receptor alpha and beta chains, together with the common gamma chain, constitute the high affinity IL2 receptor present on activated T and B cells, thymocyte subset, pre B cells and T regulatory cells. Homodimeric alpha chains result in low affinity receptor, while homodimeric beta chains produce a medium affinity receptor. Normally an integral membrane protein, soluble IL2 Receptor alpha has been isolated and determined to result from extracellular proteolysis. Alternately spliced IL2 Receptor alpha mRNAs have been isolated, but the significance of each is presently unknown. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Buffer: | PBS, BSA. pH 7.4 |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Hu, |
| Alternate Names: | anti-CD 25 antibody, anti-CD25 antibody, anti-CD25 antigen antibody, anti-IDDM10 antibody, anti-IL 2 RA antibody, anti-IL 2 receptor alpha subunit antibody, anti-IL 2R antibody, anti-IL2 RA antibody, anti-IL2R antibody, anti-IL2RA antibody, anti-IL2RAC antibody, anti-Interleukin 2 Receptor Alpha antibody, anti-Interleukin 2 receptor alpha chain antibody, anti-Ly43 antibody, anti-p55 antibody, anti-T Cell Growth Factor Receptor antibody, anti-TAC Antigen antibody, anti-TCGFR antibody |
| Package Size: | 100 tests |
| Preservative: | 15mM Sodium Azide |
| Conjugate: | FITC |
| General References: | General / background references:Leukocyte Typing VI. Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997). |
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