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| Catalog Code: | NB120-17948 |
| Product Name: | Involucrin Antibody |
| Product Description: | Mouse Monoclonal anti-Involucrin (SPM259) |
| Clone: | SPM259 |
| Clonality: | Monoclonal |
| ListPrice: | 285 |
| Immunogen: | Human keratinocytes involucrin |
| Epitope: | The epitope lies within amino acids 421-568 |
| Cross Reactivity: | Cross-reacts with Human, Rat, Dog, Gorilla and Pig.Not yet tested in other species. |
| Packaging: | 7 ml protein G purified Mouse IgG. |
| Uses: | IHC-P: Ready-to-use for 30 min at RT. Perform enzymatic antigen retrieval before commencing with IHC staining protocol.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cytoplasmic |
| Background: | Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures it is expressed by all cells that have left the basal layer. Involucrin expression is abnormal in squamous cell carcinomas and premalignant lesions and is reduced in severe dysplasias of the larynx and cervix. Its gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG1 kappa |
| Host Name: | Mouse |
| Buffer: | BSA, 10mM PBS. pH 7.4 |
| Application Summary: | immunohistochemistry-P |
| Species Summary: | Ca, Hu, Po, Mk, Rt, |
| Alternate Names: | anti-involucrin antibody, anti-ivl antibody |
| Package Size: | 7 ml |
| Preservative: | Sodium Azide |
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more information: | company product webpage |
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