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| Catalog Code: | NB120-17794 |
| Product Name: | Elastase 2 Antibody |
| Product Description: | Mouse Monoclonal anti-Elastase 2 (SPM205) |
| Clone: | SPM205 |
| Clonality: | Monoclonal |
| ListPrice: | 285 |
| Immunogen: | Human neutrophil granule proteins |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 7 ml protein G purified Mouse IgG. |
| Uses: | IHC-P: Prediluted, ready to use. Do not perform antigen retrieval.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Secreted |
| Background: | Elastases form a subfamily of serine proteases that hydrolyse many proteins in addition to elastin. Neutrophil elastase (elastase 2) hydrolyses proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. Elastase 2 may play a role in degenerative and inflammatory diseases by its proteolysis of collagen IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. When secreted at sites of inflammation elastase can cause severe tissue damage. An important role has been suggested for human elastase in various inflammatory disorders, including pulmonary emphysema, sepsis, arthritis, nephritis and certain skin diseases. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Buffer: | BSA, 10M PBS. pH 7.4 |
| Application Summary: | immunohistochemistry-P |
| Species Summary: | Hu, |
| Alternate Names: | anti-ELA 2 antibody, anti-Human leukocyte elastase antibody, anti-Bone Marrow Serine Protease antibody, anti-ELA2 antibody, anti-ELA2 elastase 2, neutrophil antibody, anti-Elastase 2 antibody, anti-Elastase 2 neutrophil antibody, anti-Elastase2 antibody, anti-ELNE antibody, anti-GE antibody, anti-HLE antibody, anti-HNE antibody, anti-Leukocyte elastase antibody, anti-Leukocyte Elastase Precursor antibody, anti-Medullasin antibody, anti-NE antibody, anti-Neutrophill elastase antibody, anti-PMN E antibody, anti-PMN Elastase antibody, anti-PMNE antibody, anti-Polymorphonuclear elastase antibody, anti-Serine protease antibody, anti-SERP1 antibody |
| Package Size: | 7 ml |
| Preservative: | Sodium Azide |
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more information: | company product webpage |
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