| CatalogCode: | NB120-17705 |
| ProductName: | GSK3 alpha Antibody |
| Product Description: | Chicken Polyclonal anti-GSK3 alpha |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide, corresponding to Internal sequence amino acids aa 89 - 100 of Human GSK3 alpha. |
| CrossReactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.05 mg IgG purified Chicken IgY |
| Uses: | ELISA: Use at an assay dependent dilution. IHC: 1/200. WB: 1/500. Predicted molecular weight: 51 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cytoplasmic |
| Background: | Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily; GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgY |
| Host_Name: | Chicken |
| Buffer: | PBS |
| ListPrice: | 285 |
| AppSummary: | ELISA, IHC, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-GSK 3 alpha antibody, anti-DKFZp686D0638 antibody, anti-Glycogen synthase kinase 3 alpha antibody, anti-GSK 3 alpha antibody, anti-GSK 3A antibody, anti-GSK3A antibody, anti-GSK3alpha antibody |
| ProteinTarget: | GSK3 alpha |
| PackageSize: | 0.05 mg |
| GeneralRef: | Nikoulina,S.E., Ciaraldi,T.P., Mudaliar,S., Carter,L., Johnson,K. and Henry,R.R. Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle Diabetes 51 (7), 2190-2198 (2002) |
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