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| Catalog Code: | NB120-17700 |
| Product Name: | Bcl xL Antibody |
| Product Description: | Chicken Polyclonal anti-Bcl xL |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Synthetic peptide, corresponding to amino acids 20-150 of Human Bcl xL. |
| Cross Reactivity: | Cross-reacts with Human, mouse, and rat. Not yet tested in other species. |
| Packaging: | 0.05 mg Immunogen affinity purified Chicken IgY |
| Uses: | IHC: 1/200. WB: 1/500. Predicted molecular weight: 28 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cell Membrane, Cytoplasmic and Nuclear membrane |
| Background: | The protein encoded by this gene belongs to the Bcl2 protein family. Bcl2 family members form hetero or homodimers and act as anti or pro apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgY |
| Host Name: | Chicken |
| Buffer: | PBS |
| Application Summary: | immunohistochemistry, Western Blot |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-Apoptosis regulator Bcl X antibody, anti-Apoptosis regulator BclX antibody, anti-B cell lymphoma 2 like antibody, anti-Bcl 2 like 1 protein antibody, anti-Bcl X antibody, anti-Bcl xL antibody, anti-BCL XL/S antibody, anti-Bcl xS antibody, anti-Bcl2 Like 1 antibody, anti-Bcl2 related gene antibody, anti-BCL2L antibody, anti-Bcl2l1 antibody, anti-BCLX antibody, anti-BclXL antibody, anti-BclXs antibody, anti-DKFZp781P2092 antibody |
| Package Size: | 0.05 mg |
| Preservative: | None |
| General References: | General / background references:Deverman BE et al. Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage. Cell 111:51-62 (2002). |
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