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| Catalog Code: | NB120-17156 |
| Product Name: | Desmin Antibody |
| Product Description: | Mouse Monoclonal anti-Desmin (D33) |
| Clone: | D33 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Full length native protein purified from human muscle.all |
| Specificity: | NB 120-17156 stains striated as well as smooth muscle cells. |
| Cross Reactivity: | Cross-reacts with Human, Rat, Chicken and Hamster. Not yet tested in other species. |
| Packaging: | 1 ml Tissue culture supernatant Mouse ascites. |
| Uses: | IHC-P: 1/25 - 1/50. We suggest an incubation period of 30 minutes at room temperature.WB: 1/50 - 1/100. Predicted molecular weight: 53 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cytoplasmic |
| Background: | Desmins belongs to the intermediate filament family, and are class III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z line structures. Defects in Desmin are the cause of desmin related cardio skeletal myopathy (CSM) also known as desmin related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin reactive deposits in cardiac and skeletal muscle cells. A desmin related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM). Defects in Desmin are also the cause of dilated cardiomyopathy type 1I (CMD1I). CMD1I is an autosomal form of dilated cardiomyopathy characterized by ventricular dilatation and impaired systolic function. Antidesmin antibodies are useful in identification of tumours of myogenic origin. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Tissue culture supernatant |
| Isotype: | IgG1 kappa |
| Host Name: | Mouse |
| Buffer: | Constituents: Tissue culture supernatant |
| Application Summary: | Immunohistochemistry-Paraffin, Western Blot, |
| Species Summary: | Ch, Ha, Hu, Rt, |
| Alternate Names: | anti-CMD1I antibody, anti-CSM1 antibody, anti-CSM2 antibody, anti-DES antibody, anti-FLJ12025 antibody, anti-FLJ39719 antibody, anti-FLJ41013 antibody, anti-FLJ41793 antibody |
| Package Size: | 1 ml |
| Preservative: | Sodium Azide |
| General References: | General / background references:Gatter KC et al. Human lung tumours may coexpress different classes of intermediate filaments. J Clin Pathol 39:950-4 (1986). Altmannsberger M et al. Desmin is a specific marker for rhabdomyosarcomas of human and rat origin. Am J Pathol 118:85-95 (1985). Miettinen M et al. Antibodies to intermediate filament proteins. The differential diagnosis of cutaneous tumors. Arch Dermatol 121:736-41 (1985). |
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