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| Catalog Code: | NB120-17110 |
| Product Name: | CD99 Ewing Sarcoma Antibody |
| Product Description: | Mouse Monoclonal anti-CD99 Ewing Sarcoma (12E7) |
| Clone: | 12E7 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Immunogen: | Acute lymphocytic leukemia T cells (Human). |
| Specificity: | This antibody reacts with CD99 expressed on the cell membrane of lymphocytes, cortical thymocytes, Langerhans' islet cells, granulosa cells of the ovary and Sertoli's cells of the testis. This antibody reacts strongly with Ewing's Sarcoma and peripheral neuroectodermal tumors. |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 6 ml protein G purified Mouse IgG. |
| Uses: | IHC-P: Prediluted, ready to use, We suggest an incubation period of 30 minutes at room temperature.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cell Membrane |
| Background: | CD99 is a 32kDa glycoprotein, which is thought to be involved in cell adhesion processes. Expression of CD99 is a characteristic of cells from Ewing's sarcoma and primitive peripheral neuroectodermal tumours. However expression is also seen in certain normal cells such as pancreatic islet cells, cortical thymocytes, Sertoli cells and ovarian granulosa cells. Mature granulocytes express very little or no CD99. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG1 kappa |
| Host Name: | Mouse |
| Buffer: | prediluted antibodies |
| Application Summary: | immunohistochemistry-P |
| Species Summary: | Hu, |
| Alternate Names: | anti-12E7 antibody, anti-Antigen identified by monoclonal 12E7 Y homolog antibody, anti-Antigen identified by monoclonal antibodies 12E7 F21 and O13 antibody, anti-CD 99 antibody, anti-CD99 antibody, anti-CD99 antigen antibody, anti-CD99 molecule antibody, anti-CD99X antibody, anti-E2 antigen antibody, anti-Ewing Sarcoma antibody, anti-MIC 2 antibody, anti-MIC 2X antibody, anti-MIC 2Y antibody, anti-MIC2 (monoclonal antibody 12E7) antibody, anti-MIC2 antibody, anti-MIC2X antibody, anti-MIC2Y antibody, anti-Monoclonal antibody 12E7 antibody, anti-MSK5X antibody, anti-Protein MIC2 antibody, anti-Surface antigen MIC2 antibody, anti-T cell surface glycoprotein E2 antibody, anti-T cell surface glycoprotein E2 precursor antibody, anti-T-cell surface glycoprotein E2 precursor antibody |
| Package Size: | 6 ml |
| General References: | General / background references:Fellinger EJ et al. Comparison of cell surface antigen HBA71 (p30/32MIC2), neuron-specific enolase, and vimentin in the immunohistochemical analysis of Ewing's sarcoma of bone. Am J Surg Pathol 16:746-55 (1992). Rettig WJ et al. Ewing's sarcoma: new approaches to histogenesis and molecular plasticity. Lab Invest 66:133-7 (1992). Ambros IM et al. MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration. Cancer 67:1886-93 (1991). |
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