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| Catalog Code: | NB120-17068 |
| Product Name: | Cytokeratin 5+6 Antibody |
| Product Description: | Mouse Monoclonal anti-Cytokeratin 5+6 (D5/16B4) |
| Clone: | D5/16B4 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Immunogen: | Human cytokeratin 5. |
| Specificity: | Cytokeratin 5 (58 kD) is a high molecular weight, basic type of cytokeratin expressed in basal, the intermediate and the superficial cell layers of stratified epithelia as well as transitional epithelia, complex epithelia and in mesothelial cells and mesothelioma. Cytokeratin 6 (56 kD) is also a high molecular weight, basic type cytokeratin expressed by proliferating squamous epithelium often paired with cytokeratin 16. |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 6 ml purified Mouse IgG. |
| Uses: | IHC-P: Prediluted and ready to use. We suggest an incubation of 30 minutes. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.IHC-Fr: Prediluted and ready to use on acetone fixed cryostat sections. We suggest an incubation of 30 minutes. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cytoplasmic |
| Background: | Cytokeratin 5 (58 kD) is a high molecular weight, basic type of cytokeratin expressed in basal, the intermediate and the superficial cell layers of stratified epithelia as well as transitional epithelia, complex epithelia and in mesothelial cells and mesothelioma. Cytokeratin 6 (56 kD) is also a high molecular weight, basic type cytokeratin expressed by proliferating squamous epithelium often paired with Cytokeratin 16. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Isotype: | IgG1 kappa |
| Host Name: | Mouse |
| Application Summary: | immunohistochemistry-Fr, immunohistochemistry-P |
| Species Summary: | Hu, |
| Alternate Names: | anti- Cytokeratin 6 antibody, anti-58 kDa cytokeratin antibody, anti-CK 5 antibody, anti-CK5 antibody, anti-Cytokeratin 5 antibody, anti-Cytokeratin5 antibody, anti-DDD antibody, anti-EBS 2 antibody, anti-EBS2 antibody, anti-K5 antibody, anti-Keratin 5 antibody, anti-Keratin 6 alpha antibody, anti-Keratin type II cytoskeletal 5 antibody, anti-Keratin5 antibody, anti-KRT 5 antibody, anti-KRT 5A antibody, anti-KRT 6 antibody, anti-KRT5 antibody, anti-KRT5A antibody |
| Package Size: | 6 ml |
| Preservative: | Sodium Azide |
| General References: | General / background references:Cury PM et al. Value of the mesothelium-associated antibodies thrombomodulin, cytokeratin 5/6, calretinin, and CD44H in distinguishing epithelioid pleural mesothelioma from adenocarcinoma metastatic to the pleura. Mod Pathol 13:107-12 (2000). Otterbach F et al. Cytokeratin 5/6 immunohistochemistry assists the differential diagnosis of atypical proliferations of the breast. Histopathology 37:232-40 (2000). |
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