| CatalogCode: | NB120-16829 |
| ProductName: | PDGF beta Antibody |
| Product Description: | Rabbit Polyclonal anti-PDGF beta |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide: TEVFEISRRLIDRTNA, corresponding to amino acids 101-116 of PDGF. |
| CrossReactivity: | Cross-reacts with Human and Rat. Expected to cross-react with Mouse (87% identity with immunogen), Cat (93% identity with immunogen), Dog (100% identity with immunogen) and Sheep (93% identity with immunogen) due to sequence homology.Not yet tested in other species. |
| Packaging: | 1 ml Affinity purified Rabbit antisera. |
| Uses: | WB: Predicted molecular weight: 27 kDa. Optimal dilutions/concentrations should be determined by the end user. |
| Control: | Mesenchymal cells. |
| Background: | PDGFB is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor alpha polypeptide, where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. The PDGF protein has also been implicated both directly and indirectly in several pathological states including neoplasia, arthritis, arteriosclerosis and bone marrow sclerosis. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Constituents: 0.2% Gelatin, 0.05M Sodium phosphate |
| ListPrice: | 325 |
| AppSummary: | IF, WB, ICC, IHC-P |
| SpeciesSummary: | Hu, Rt |
| ALTnames: | anti-Becaplermin antibody, anti-c-sis antibody,anti-FLJ12858 antibody, anti-oncogene SIS antibody, anti-PDGF 2 antibody, anti-PDGF B antibody, anti-PDGF B chain antibody, anti-PDGF2 antibody, anti-PDGFB antibody, anti-Platelet derived growth factor 2 antibody, anti-Platelet derived growth factor B chain antibody, anti-Platelet derived growth factor beta antibody, anti-Platelet derived growth factor beta polypeptide antibody, anti-Platelet-derived growth factor beta polypeptide antibody, anti-Simian sarcoma viral (v-sis) oncogene homolog antibody, anti-SIS antibody, anti-SSV antibody, anti-v-sis platelet derived growth factor beta polypeptide antibody |
| ProteinTarget: | PDGF beta |
| PackageSize: | 1 ml |
| GeneralRef: | General / background references:LaRochelle WJ et al. Immunochemical localization of the epitope for a monoclonal antibody that neutralizes human platelet-derived growth factor mitogenic activity. Mol Cell Biol 9:3538-42 (1989). Hannink M et al. Deletions in the C-terminal coding region of the v-sis gene: dimerization is required for transformation. Mol Cell Biol 6:1304-14 (1986). Ross R et al. The biology of platelet-derived growth factor. Cell 46:155-69 (1986). |
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