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| Catalog Code: | NB120-16702 |
| Product Name: | CD23 Antibody |
| Product Description: | Rabbit Monoclonal anti-CD23 (SP23) |
| Clone: | SP23 |
| Clonality: | Monoclonal |
| ListPrice: | 285 |
| Immunogen: | Recombinant fragment, corresponding to amino acids 48-248 of Human CD23. |
| Specificity: | This antibody recognizes CD23. CD23 is a 45kDa glycoprotein, which is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. The CD23 molecule is identical to the low affinity IgE receptor found on B cells. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocyctic leukaemia and some cases of centroblastic/centrocytic lymphoma.This antibody crossreacts with Human. |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.5 ml Rabbit Tissue culture supernatant |
| Uses: | IHC-P: 1/100. Retrieve antigens with 70% Formic acid for 10-30 minutes at room temperature before commencing with IHC staining protocol.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cell Membrane |
| Background: | The CD23 antigen is the low affinity IgE Fc receptor, which is a 49 kDa protein with 38 and 28 kDa fragments. It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells), and can also be found on the surface of T cells, macrophages, platelets and EBV transformed B lymphoblasts. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic Lymphocytic leukemia. CD23 is expressed by B cells in the follicular mantle but not by proliferating germinal centre cells. CD23 is also expressed by eosinophils. CD23 is distinct from the high affinity IgE receptors found on basophils and mast cells, which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system, which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a membrane bound cytokine," in that the soluble cleavage products of CD23 are themselves able to act as cytokines in vitro. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Tissue culture supernatant |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Application Summary: | immunohistochemistry-P |
| Species Summary: | Hu, |
| Alternate Names: | anti-Blast 2 antibody, anti-CD23 Antigen antibody, anti-FC Epsilon RII antibody, anti-FC Receptor IgE Low Affinity II Alpha Polypeptide antibody, anti-FCER2A antibody, anti-IgE Binding Factor antibody, anti-IgE Receptor Lymphocyte antibody, anti-IGEBF antibody, anti-Low Affinity immunoglobulin Epsilon FC Receptor Membrane Bound Form antibody, anti-Low Affinity Immunoglobulin Epsilon FC Receptor Soluble Form antibody, anti-Ly42 antibody |
| Package Size: | 0.5 ml |
| Preservative: | 0.1 % sodium azide (NaN3) |
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