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| Catalog Code: | NB120-16460 |
| Product Name: | Estrogen Receptor Antibody |
| Product Description: | Mouse Monoclonal anti-Estrogen Receptor (TE111.5D11) |
| Clone: | TE111.5D11 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Concentration: | 1 mg/ml |
| Immunogen: | Recombinant fragment, corresponding to amino acids 302-595 of Human Estrogen Receptor. |
| Cross Reactivity: | Cross-reacts with Human, Mouse and Rat. Not yet tested in other species. |
| Packaging: | 0.05 mg IgG purified Mouse ascites. |
| Uses: | GSA: Use neat.Neut: Use at an assay dependent dilution. This antibody can be used to block binding of estrogen to the estrogen receptor.WB: Use at a concentration of 1 - 2 ug/ml. Predicted molecular weight: 66 kDa. IP: Use at a concentration of 2 ug/mg of protein lysate on native and denatured lysate. |
| Localization: | Nuclear |
| Background: | The estrogen receptor (ER) is a 66 kDa protein that mediates the actions of estrogens in estrogen responsive tissues. It is a member of a large superfamily of nuclear hormone receptors that function as ligand activated transcription factors. The ER gene consists of more than 140 kb of genomic DNA divided into 8 exons. These translate into a protein with six functionally discrete domains, labeled A through F. A second form of the estrogen receptor, ER beta has recently been described. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti estrogen (e.g. tamoxifen) therapy. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Buffer: | PBS |
| Application Summary: | immunoprecipitation , Western Blot , Gel Super Shift Assays , Neut, |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-DKFZp686N23123 antibody, anti-ER Alpha antibody, anti-ER antibody, anti-ERA antibody, anti-ESR 1 antibody, anti-ESR antibody, anti-ESR1 antibody, anti-ESRA antibody, anti-Estradiol Receptor antibody, anti-Estrogen receptor 1 antibody, anti-NR3A 1 antibody, anti-NR3A1 antibody |
| Package Size: | 0.05 mg |
| Preservative: | 0.08% Sodium Azide |
| General References: | General / background references:Abbondanza C et al. Characterization and epitope mapping of a new panel of monoclonal antibodies to estradiol receptor. Steroids 58:4-12 (1993). |
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more information: | company product webpage |