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| Catalog Code: | NB120-16423 |
| Product Name: | Calpastatin Antibody |
| Product Description: | Chicken Polyclonal anti-Calpastatin |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Concentration: | 1 mg/ml |
| Immunogen: | Recombinant fragment, corresponding to amino acids 1-137 of Human Calpastatin, corresponding to domain I. |
| Cross Reactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.05 mg Immunogen affinity purified Chicken IgY |
| Uses: | ELISA: Use at a concentration of 1 ug/ml. WB: 1/500. Predicted molecular weight: 76 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cytoplasmic and Nuclear |
| Background: | Calpastatin is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgY |
| Host Name: | Chicken |
| Buffer: | PBS |
| Application Summary: | ELISA, Western Blot |
| Species Summary: | Hu, |
| Alternate Names: | anti-Calpain inhibitor antibody, anti-CAST antibody, anti-Heart type calpastatin antibody, anti-MGC9402 antibody, anti-Sperm BS 17 component antibody |
| Package Size: | 0.05 mg |
| Preservative: | None |
| General References: | General / background references:Li S et al. Molecular cloning and characterization of functional domains of a human testis-specific isoform of calpastatin. Biol Reprod 63:172-8 (2000). |
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