| CatalogCode: | NB120-16420 |
| ProductName: | beta Synuclein Antibody |
| Product Description: | Chicken Polyclonal anti-beta Synuclein |
| Clonality: | Polyclonal |
| Immunogen: | Fusion protein, corresponding to amino acids 1-134 of Human beta Synuclein. |
| CrossReactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.05 mg IgG purified Chicken IgY |
| Uses: | WB: 1/2000. Predicted molecular weight: 15 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cytoplasmic. |
| Control: | E.Coli derived fusion protein. |
| Background: | Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors. The family includes three known proteins: alpha synuclein, beta synuclein, and gamma synuclein. The alpha and beta synuclein proteins are found primarily in brain tissue, where they are seen mainly in presynaptic terminals. Beta synuclein protein is found in Alzheimer disease neurofibrillary lesions. The sequence of beta synuclein is 61% identical to alpha synuclein, which is also present in these lesions. Beta synuclein is an acidic protein and extremely heat-resistant. It has a chaperone-like activity and has been suggested to inhibit alpha synuclein aggregation. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgY |
| Host_Name: | Chicken |
| Buffer: | PBS |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Phosphoneuroprotein 14 antibody, anti-PNP14 antibody, anti-SNCB antibody, anti-Synuclein beta antibody |
| ProteinTarget: | beta Synuclein |
| PackageSize: | 0.05 mg |
| GeneralRef: | General / background references:da Costa CA et al. Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: cross-talk with alpha-synuclein and implication for Parkinson's disease. J Biol Chem 278:37330-5 (2003). |
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