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| Catalog Code: | NB120-16231 |
| Product Name: | CCR3 Antibody |
| Product Description: | Mouse Monoclonal anti-CCR3 (5E8) |
| Clone: | 5E8 |
| Clonality: | Monoclonal |
| ListPrice: | 285 |
| Concentration: | 1 mg/ml |
| Immunogen: | Tissue / cell preparation (Human) - human CCR3 transfected into mouse B cell lymphoma L1.2 cells. |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.1 mg Affinity purified Mouse IgG. |
| Uses: | Additional reported applications (for the relevant formats) include: The 5E8 antibody is useful for immunofluorescent staining and flow cytometric analysis of CCR3 expression |
| Localization: | Integral membrane protein. |
| Background: | CCR3 is a receptor for CC chemokine eotaxin 1 and eotaxin 2. CCR3 has been reported in blood, brain, lung, bone marrow, kidney, liver, lymph node, placenta, skin, spleen, thymus, thyroid, uterus, and vessel. Within these tissues, CCR3 is expressed in specific cell types, including eosinophils, basophils, Th2 cells, and mast cells. The agonists for CXCR3 (IP-10, mig, and I-TAC) act as antagonists for CCR3 by competing for the binding of eotaxin to CCR3. The 356 amino acid CCR3 receptor is expressed on human eosinophils, basophils, neutrophils, mast cells, mononuclear phagocytes, platelets, CD34+ hematopoietic progenitor cells, Th2 like lymphocytes, and keratinocytes. CCR3 is thought to play a key role in allergic diseases such as bronchial asthma and allergic rhinitis. CCR3 is a co-receptor for HIV 1 and 2 and the binding of eotaxin with CCR3 has been shown to inhibit HIV infection in some cell types. The CCR3 receptor has been reported to be upregulated by high affinity Fc IgE receptor ligation. |
| Storage: | The antibody solution should be stored undiluted at 4°C. |
| Purity: | Affinity purified |
| Isotype: | IgG2a |
| Host Name: | Mouse |
| Buffer: | Phosphate-buffered solution, pH 7.2 |
| Application Summary: | flow cytometry / FACS analysis , immunofluorescence |
| Species Summary: | Hu, |
| Alternate Names: | anti-B Chemokine Receptor antibody, anti-C C chemokine receptor type 3 antibody, anti-C C CKR 3 antibody, anti-CC Chemokine Receptor 3 antibody, anti-CC chemokine receptor type 3 antibody, anti-CC CKR 3 antibody, anti-CC R3 antibody, anti-CCCKR3 antibody, anti-CCR 3 antibody, anti-CD 193 antibody, anti-CD193 antibody, anti-CD193 antigen antibody, anti-Chemokine (C C motif) receptor 3 antibody, anti-Chemokine (CC) Receptor 1 Like 2 antibody, anti-Chemokine CC Motif Receptor 3 antibody, anti-Chemokine receptor 3 antibody, anti-CK R3 antibody, anti-CKR 3 antibody, anti-CKR3 antibody, anti-CMKB R3 antibody, anti-CMKBR 3 antibody, anti-CMKBR1L2 antibody, anti-CMKBR3 antibody, anti-Eosinophil CC Chemokine Receptor 3 antibody, anti-Eosinophil Eotaxin Receptor antibody, anti-Eotaxin Receptor antibody, anti-Macrophage Inflammatory Protein1 Alpha Receptor Like 2 antibody, anti-MGC102841 antibody, anti-MIP1 Alpha RL2 antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.09% Sodium Azide (NaN3) |
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