| CatalogCode: | | NB120-16151 |
| ProductName: | | Prostaglandin E Receptor EP2 Antibody |
| Product Description: | | Mouse Monoclonal anti-Prostaglandin E Receptor EP2 (3E6) |
| Clone: | | 3E6 |
| Clonality: | | Monoclonal |
| Immunogen: | | Recombinant human Prostaglandin E Receptor EP2 protein. |
| CrossReactivity: | | Cross-reacts with Human, Rat and Cow. Not yet tested in other species. |
| Packaging: | | 0.05 mg IgG purified Mouse ascites. |
| Uses: | | WB: Use at a concentration of 1 - 5 ug/ml. Detects a band of approximately 53 kDa. Not tested in other applications. |
| Localization: | | Cell Membrane |
| Control: | | Porcine brain lysate |
| Background: | | Prostaglandins are produced by the metabolism of arachidonic acid. Prostaglandin E2 is one of the five physiologically significant prostanoids known. Its wide spectrum of physiologic and pharmacologic effects in various tissues is mediated through binding to the Prostaglandin E2 receptors (EP1, EP2, EP3 & EP4). These include effects on the immune, endocrine, cardiovascular, renal and reproductive systems as well as smooth muscle. It is also one of the most abundant of the prostanoid family in the brain where it plays an important role in many neural functions, particularly in newborn babies, and as a mediator of inflammation. Prostaglandin E2 signals through a family of G-protein coupled receptors known as EP receptors. There are 4 subtypes of EP receptors, known as EP1, EP2, EP3 and EP4. EP2 receptors are 358 amino acid proteins with a short third intracellular loop. EP2 receptors stimulate adenylyl cyclase by their coupling to Gs and do not undergo Prostaglandin E2 induced internalization. The EP2 receptors is involved with the contration and relaxation of smooth muscle tissue. These receptors are mainly localized in lung and placental tissues and in smooth muscle. |
| Storage: | | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | | IgG purified |
| Isotype: | | IgG |
| Host_Name: | | Mouse |
| Buffer: | | PBS |
| ListPrice: | | 325 |
| AppSummary: | | WB |
| SpeciesSummary: | | Bv, Hu, Rt |
| ALTnames: | | anti-15 hydroxyprostaglandin dehydrogenase [NAD+] antibody, anti-15 PGDH antibody, anti-HPGD antibody, anti-PGDH antibody, anti-PGDH1 antibody |
| ProteinTarget: | | Prostaglandin E Receptor EP2 |
| PackageSize: | | 0.05 mg |
| GeneralRef: | | General / background references:Desai S et al. Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: role of the carboxyl terminus in EP4 receptor sequestration. Mol Pharmacol 58:1279-86 (2000). Morath R et al. Immunolocalization of the four prostaglandin E2 receptor proteins EP1, EP2, EP3, and EP4 in human kidney. J Am Soc Nephrol 10:1851-60 (1999). Bhattacharya M et al. Nuclear localization of prostaglandin E2 receptors. Proc Natl Acad Sci U S A 95:15792-7 (1998). Fedyk ER & Phipps RP Prostaglandin E2 receptors of the EP2 and EP4 subtypes regulate activation and differentiation of mouse B lymphocytes to IgE-secreting cells. Proc Natl Acad Sci U S A 93:10978-83 (1996). |
| more information: | | company product webpage |