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| Catalog Code: | NB120-16149 |
| Product Name: | RAD1 Antibody |
| Product Description: | Mouse Monoclonal anti-RAD1 (63) |
| Clone: | 63 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Concentration: | 0.2 mg/ml |
| Immunogen: | Recombinant full length protein (Human). |
| Cross Reactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.1 ml IgG purified Mouse IgG. |
| Uses: | IP: Use at an assay dependent dilution. WB: Detects a band of approximately 31 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Nuclear |
| Background: | Human Rad1 is a component of a heterotrimeric PCNA-like complex that also contains the Rad9 and Hus1 proteins. This complex is believed to be involved in cellular responses to DNA damage, possibly by associating with Rad17 and several components of the PCNA-loading heteropentamer, replication factor C. Human Rad1 exhibits significant homology to Rad1 from S. pombe, and its expression in yeast rad1 mutants has been shown to partially restore radiation resistance and G2-checkpoint activity. It has also been shown to possess exonuclease activity. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG2a |
| Host Name: | Mouse |
| Buffer: | PBS |
| Application Summary: | immunoprecipitation , Western Blot 1 ug/ml |
| Species Summary: | Hu, |
| Alternate Names: | anti-Cell cycle checkpoint protein Hrad1 antibody; anti-Cell cycle checkpoint protein Rad 1 A / B antibody; anti-DNA repair exonuclease antibody; anti-REC 1 antibody |
| Package Size: | 0.1 ml |
| Preservative: | Sodium Azide |
| General References: | General / background references:Durant ST et al. Dependence on RAD52 and RAD1 for anticancer drug resistance mediated by inactivation of mismatch repair genes. Curr Biol 9:51-4 (1999). Volkmer E & Karnitz LM Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex. J Biol Chem 274:567-70 (1999). Marathi UK et al. RAD1, a human structural homolog of the Schizosaccharomyces pombe RAD1 cell cycle checkpoint gene. Genomics 54:344-7 (1998). |
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