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| Catalog Code: | NB120-15552 |
| Product Name: | Caspase 8 Antibody |
| Product Description: | Rabbit Polyclonal anti-Caspase 8 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Recombinant full length human caspase 8 protein. |
| Cross Reactivity: | Cross-reacts with Human, Mouse, Rat, Cow and Monkey.Not yet tested in other species. |
| Packaging: | 7 ml Affinity purified Rabbit IgG. |
| Uses: | IHC-P: Use at an assay dependent dilution. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cytoplasmic |
| Background: | Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase 8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase 3 and Caspase 7, which in turn cause cell collapse. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 10mM PBS, pH 7.4 with BSA |
| Application Summary: | immunohistochemistry-P |
| Species Summary: | Bv, Hu, Mu, Mk, Rt, |
| Alternate Names: | anti-Apoptosis related cysteine peptidase antibody, anti-Apoptotic cysteine protease antibody, anti-Apoptotic protease Mch 5 antibody, anti-CAP 4 antibody, anti-CAP4 antibody, anti-CASP 8 antibody, anti-CASP8 antibody, anti-Caspase8 antibody, anti-CED 3 antibody, anti-FADD homologous ICE/CED 3 like protease antibody, anti-FADD Homologous ICE/CED3 Like Protease antibody, anti-FADD Like ICE antibody, anti-FLICE antibody, anti-ICE like apoptotic protease 5 antibody, anti-MACH antibody, anti-MCH 5 antibody, anti-MCH5 antibody, anti-MGC78473 antibody, anti-MORT1 associated CED 3 homolog antibody, anti-MORT1 associated CED3 homolog antibody |
| Package Size: | 7 ml |
| Preservative: | Sodium Azide |
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more information: | company product webpage |
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