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| Catalog Code: | NB120-15550 |
| Product Name: | Caspase 1 Antibody |
| Product Description: | Rabbit Polyclonal anti-Caspase 1 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Synthetic peptide (Human, Internal sequence-second quarter of human Caspase 1 protein). |
| Cross Reactivity: | Cross-reacts with Human, Mouse and Rat.Not yet tested in other species. |
| Packaging: | 7 ml Immunogen affinity purified Rabbit IgG. |
| Uses: | IHC-P: Use at an assay dependent dilution. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cytoplasmic |
| Background: | Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a2b2 tetramer to form the active enzyme. Caspase 1 is similar to the cell death gene CED3 of C. elegans and regulates multiple proinflammatory cytokines, including Interleukin 1b and interferon-gamma-inducing factor. Caspase 1 plays a role down stream of Caspase 8 which is involved in Fas-mediated apoptosis. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | PBS, BSA |
| Application Summary: | immunohistochemistry-P |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-CASP 1 antibody, anti-CASP1 antibody, anti-Caspase 1 apoptosis related cysteine peptidase antibody, anti-Caspase 1 apoptosis related cysteine protease antibody, anti-Caspase1 antibody, anti-ICE antibody, anti-IL 1 beta converting enzyme antibody, anti-IL 1BC antibody, anti-IL1B convertase antibody, anti-IL1BC antibody, anti-IL1BCE antibody, anti-Interleukin 1 beta convertase antibody, anti-Interleukin 1 beta convertase precursor antibody, anti-Interleukin 1 beta converting enzyme antibody, anti-Interleukin 1B converting enzyme antibody, anti-P45 antibody |
| Package Size: | 7 ml |
| Preservative: | Sodium Azide |
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more information: | company product webpage |
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