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| Catalog Code: | NB120-15549 |
| Product Name: | Presenilin 2 Antibody |
| Product Description: | Mouse Monoclonal anti-Presenilin 2 (APS 26) |
| Clone: | APS 26 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Concentration: | 1 mg/ml |
| Immunogen: | Synthetic peptide: CLPYDPEMEEDSYDSFGEP, corresponding to amino acids 317-334 of Human Presenilin 2 with N-terminally added cysteine. |
| Specificity: | No cross-reactivity is seen with presenilin 1. |
| Cross Reactivity: | Cross-reacts with Human, Mouse and Rat.Expected to cross-react with Cow (100% identity with immunogen) due to sequence homology.Not yet tested in other species. |
| Packaging: | 0.2 mg protein G purified Mouse IgG. |
| Uses: | ELISA: Use at a concentration of 4.5 ug/ml. IF: Use at a concentration of 0.75 ug/ml. WB: Use at a concentration of 12 ug/ml. Detects a band of approximately 20 and 45 kDa, corresponding to C-terminal and full length fragments.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cell Membrane, Endoplasmic reticulum and Golgi Apparatus |
| Background: | Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified. |
| Storage: | Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Buffer: | PBS, 1mg/ml BSA |
| Application Summary: | ELISA, immunofluorescence, Western Blot |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-AD 3L antibody, anti-AD 3LP antibody, anti-AD 4 antibody, anti-AD 5 antibody, anti-AD3L antibody, anti-AD3LP antibody, anti-AD4 antibody, anti-AD5 antibody, anti-Alzheimer disease 4 antibody, anti-Alzheimer Disease Familial Type 4 antibody, anti-Alzheimer's disease 3 like antibody, anti-E5 1 antibody, anti-EC 3.4.23. antibody, anti-Presenilin2 antibody, anti-PS 2 antibody, anti-PS2 antibody, anti-PSEN 2 antibody, anti-PSEN2 antibody, anti-PSNL 2 antibody, anti-PSNL2 antibody, anti-STM 2 antibody, anti-STM2 antibody |
| Package Size: | 0.2 mg |
| Preservative: | 0.05% Sodium Azide |
| General References: | General / background references:Diehlmann A et al. Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies. J Neurosci Res 56:405-19 (1999). Tesco G et al. Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation. J Biol Chem 273:33909-14 (1998). |
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