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| Catalog Code: | NB120-15535 |
| Product Name: | Synuclein Antibody |
| Product Description: | Rabbit Polyclonal anti-Synuclein |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | A synthetic peptide corresponding to near N-terminal of human alpha, beta, pan-Synuclein protein. |
| Cross Reactivity: | Cross-reacts with Human and Rat.Not yet tested in other species. |
| Packaging: | 7 ml Affinity purified Rabbit IgG. |
| Uses: | IHC-P: Working dilution: ready-to-use for 10 min at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cytoplasmic |
| Background: | Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors. The family includes three known proteins: alpha, beta and gamma synucleins. Synuclein-alpha is primarily localized at the presynaptic region of axons and it may be involved in the regulation of dopamine release and transport. However, it can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Synuclein-alpha may induce fibrillization of the microtubule-associated protein tau and it reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Synuclein-alpha is involved in Parkinson's disease, Lewy body dementia, Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome) and it is a major non-amyloid component of the deposits associated with Alzheimer's disease. Synuclein-beta may be a regulator of the SNCA aggregation process. It protects neurons from staurosporine and 6 hydroxy dopamine (6OHDA)-stimulated caspase activation that also involves p53 and contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Gamma synuclein is found primarily in the peripheral nervous system and retina. High levels of expression have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | BSA, 10mM PBS. pH 7.4 |
| Application Summary: | immunohistochemistry-P |
| Species Summary: | Hu, Rt, |
| Alternate Names: | anti-Non-A beta component of AD amyloid antibody, anti-Non-A4 component of amyloid precursor antibody, anti-NACP antibody |
| Package Size: | 7 ml |
| Preservative: | Sodium Azide |
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more information: | company product webpage |