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| Catalog Code: | NB120-15521 |
| Product Name: | S100 Antibody |
| Product Description: | Rabbit Polyclonal anti-S100 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Recombinant protein encoding human S100 protein. |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 7 ml Immunogen affinity purified Rabbit IgG. |
| Uses: | IHC-P: Prediluted antibody which is ready to use for 10 min at room temperature. No special pretreatment is required for histochemical staining of formalin/paraffin tissues. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cytoplasmic |
| Background: | S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. S100 protein may function in stimulation of Ca2+ induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. Immunoreactive S100 protein localizes in the cytoplasm and nuclei of astrocytes, Schwann's cells, ependymomas and astrogliomas. Ganglion cells do not stain for S100 protein. S100 can be detected in almost all benign naevi and malignant melanocytic tumours of the skin, and in Langerhans cells in the skin. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 10mM PBS, pH 7.4 with BSA |
| Application Summary: | immunohistochemistry-P |
| Species Summary: | Hu, |
| Alternate Names: | anti-Bpb antibody, anti-NEF antibody, anti-S 100 PROTEIN BETA CHAIN antibody, anti-S100 alpha antibody, anti-S100 calcium binding protein A1 antibody, anti-S100 calcium binding protein beta neural antibody, anti-S100 protein alpha chain antibody, anti-S100 protein alpha polypeptide antibody, anti-S100 protein beta polypeptide neural antibody, anti-S100A antibody, anti-S100a1 antibody, anti-S100B antibody |
| Package Size: | 7 ml |
| Preservative: | Sodium Azide |
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more information: | company product webpage |