| CatalogCode: | NB120-15494 |
| ProductName: | Parkin Antibody |
| Product Description: | Rabbit Polyclonal anti-Parkin |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) (Human) (N terminal). |
| CrossReactivity: | Cross-reacts with Human, Mouse and Rat.Not yet tested in other species. |
| Packaging: | 0.05 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | IHC-P: Use at a dilution of 1/30 for 10 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 minutes followed by cooling at RT for 20 minutes. Ab15494 demonstrates cytoplasmic staining.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Control: | Brain |
| Background: | Parkinson's disease is a common neurodegenerative disease with complex clinical features. Mutations in the gene, Parkin (PARK2), appear to be responsible for the pathogenesis of autosomal recessive juvenile Parkinsonism. Parkin plays a role in the ubiquitin-mediated proteolytic pathway by removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of Parkin. Parkin may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, gpr37 accumulation, and kainate-induced excitotoxicity. It may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Parkin also regulates cyclin e during neuronal apoptosis and may represent a tumor suppressor gene. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Preservative: Sodium AzideConstituents: 10mM PBS, BSA. pH 7.4 |
| ListPrice: | 295 |
| AppSummary: | IHC-P |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-Ubiquitin E3 ligase PRKN antibody, anti-Parkinson juvenile disease protein 2 antibody, anti-Parkinson disease protein 2. GENE NAME: PARK2 antibody, anti-PRKN antibody |
| ProteinTarget: | Parkin |
| PackageSize: | 0.05 mg |
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