| CatalogCode: | NB120-15458 |
| ProductName: | Presenilin 1 Antibody |
| Product Description: | Mouse Monoclonal anti-Presenilin 1 (APS 18) |
| Clone: | APS 18 |
| Clonality: | Monoclonal |
| Immunogen: | Synthetic peptide: SKYNAESTERESQDTVAENDDG, corresponding to amino acids 313-334 of Human Presenilin 1 with N-terminally added cysteine. |
| CrossReactivity: | Cross-reacts with Human, Mouse and Rat.Expected to cross-react with Cynomolgus Monkey (100% identity with immunogen) due to sequence homology.Not yet tested in other species. |
| Packaging: | 0.2 mg |
| Uses: | ELISA: Use at a concentration of 1 ug/ml. IF: Use at a concentration of 6 ug/ml. WB: Use at a concentration of 12 ug/ml. Predicted molecular weight: 56 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Integral membrane protein. Golgi and endoplasmic reticulum. Bound to NOTCH1 also at the cell surface. |
| Purity: | Protein G purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | PBS with 0.05% sodium azide |
| ListPrice: | 330 |
| AppSummary: | ELISA, IF, WB |
| ProteinTarget: | Presenilin 1 |
| PackageSize: | 0.2 mg |
| GeneralRef: | General / background references:Stahl B et al. Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071. J Biol Chem 274:9141-8 (1999). Diehlmann A et al. Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies. J Neurosci Res 56:405-19 (1999). Tesco G et al. Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation. J Biol Chem 273:33909-14 (1998). |
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