| CatalogCode: | NB120-15306 |
| ProductName: | GRM4 Antibody |
| Product Description: | Rabbit Polyclonal anti-GRM4 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide (Human) (C terminal). |
| CrossReactivity: | Cross-reacts with Human, Mouse, Rat, Chicken and Monkey.Not yet tested in other species. |
| Packaging: | 7 ml Immunogen affinity purified Rabbit IgG. |
| Uses: | IHC-P: Working dilution, ready to use for 10 minutes at RT. Staining of formalin fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at RT for 20 minutes. Ab15306 demonstrates cytoplasmic staining.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Integral membrane protein |
| Control: | Brain |
| Background: | L glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | prediluted antibody |
| ListPrice: | 285 |
| SpeciesSummary: | Ch, Hu, Mu, Mk, Rt |
| ALTnames: | anti-G protein coupled receptor family C group 1 member D antibody, anti-G protein coupled receptor GRM 4 antibody, anti-G protein coupled receptor GRM4 antibody, anti-Glutamate Receptor Metabotropic 4 antibody, anti-GPRC 1D antibody, anti-Gprc1d antibody, anti-GRM 4 antibody, anti-GRM4 antibody, anti-Metabotropic glutamate receptor 4 antibody, anti-mGlu 4 antibody, anti-mGlu R4 antibody, anti-mGlu4 antibody, anti-mGluR 4 antibody, anti-mGluR4 antibody |
| ProteinTarget: | GRM4, prediluted |
| PackageSize: | 7 ml |
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