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| Catalog Code: | NB120-15274 |
| Product Name: | Bcl x Antibody |
| Product Description: | Rabbit Polyclonal anti-Bcl x |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Concentration: | 0.2 mg/ml |
| Immunogen: | Synthetic peptide: ETPSAINGNPSWHLADSPAVN, corresponding to amino acids 46-66 of Human Bcl x. |
| Cross Reactivity: | Cross-reacts with Human and Mouse.Expected to cross-react with Rat (100% identity with immunogen), Cat (100% identity with immunogen), Dog (100% identity with immunogen), Pig (100% identity with immunogen) and Sheep (100% identity with immunogen) due to sequence homology.Not yet tested in other species. |
| Packaging: | 0.5 ml Immunogen affinity purified Rabbit IgG. |
| Uses: | IHC-P: Use at a dilution of 1/200 for 10 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0 for 10 minutes followed by cooling at RT for 20 minutes.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Mitochondrial membranes and perinuclear envelope |
| Background: | The protein encoded by this gene belongs to the Bcl2 protein family. Bcl2 family members form hetero or homodimers and act as anti or pro apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 10mM PBS, BSA. pH 7.4 |
| Application Summary: | immunohistochemistry-P |
| Species Summary: | Hu, Mu, |
| Alternate Names: | anti-Apoptosis regulator Bcl X antibody, anti-Bcl 2 like 1 antibody, anti-Bcl 2 like 1 protein antibody, anti-Bcl xL antibody, anti-BCL XL/S antibody, anti-Bcl xS antibody, anti-Bcl2 like1 antibody, anti-BCL2L antibody, anti-BCL2L1 antibody, anti-Bclx antibody, anti-DKFZp781P2092 antibody |
| Package Size: | 0.5 ml |
| Preservative: | Sodium Azide |
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more information: | company product webpage |