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| Catalog Code: | NB120-15239 |
| Product Name: | SYK Antibody |
| Product Description: | Mouse Monoclonal anti-SYK (SPM147) |
| Clone: | SPM147 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Synthetic peptide: RQESTVSFNPYEPELAPWAADKGPQRE, corresponding to amino acids 313-339 of Human Syk. |
| Cross Reactivity: | Cross-reacts with Human. Does not cross-react with Mouse or Pig. Not yet tested in other species. |
| Packaging: | 7 ml protein G purified Mouse IgG. |
| Uses: | IHC-P: Ready to use. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cytoplasmic (probable) |
| Background: | Syk (72 kDa) is a non-receptor protein tyrosine kinase that plays an important role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration. SYK is a positive effector of BCR stimulated responses. It couples the B cell antigen receptor (BCR) to the mobilization of calcium ions either through a phosphoinositide 3 kinase dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C gamma dependent pathway, when phosphorylated on Tyr 342 and Tyr 346. Thus the differential phosphorylation of SYK can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ions. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG2a kappa |
| Host Name: | Mouse |
| Buffer: | prediluted antibody |
| Application Summary: | immunohistochemistry-P |
| Species Summary: | Hu, Mu(-), Po(-), |
| Alternate Names: | anti-GCIP interacting protein p29 antibody, anti-P29 antibody, anti-CBPIN antibody, anti-NTC31 antibody, anti-DFKZP564O2082 antibody |
| Package Size: | 7 ml |
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more information: | company product webpage |