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| Catalog Code: | NB120-15236 |
| Product Name: | Serotonin Antibody |
| Product Description: | Mouse Monoclonal anti-Serotonin (SPM146) |
| Clone: | SPM146 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | 5 Hydroxytryptamine hydrochloride (3,(2 aminoethyl) 5 hydroxyindole; serotonin). |
| Cross Reactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 1 ml Mouse Tissue culture supernatant |
| Uses: | Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. The optimal dilution for a specific application should be determined by the investigator. |
| Localization: | Cytoplasmic |
| Background: | Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter synthesised in serotonergic neurons in the central nervous system and enterochromaffin cells in the gastrointestinal tract. Serotonin plays an important part in the biochemistry of depression, migraine, bipolar disorder and anxiety. It is also believed to be influential on sexuality and appetite. 5-HT is generally thought not to be released from synaptic terminal buttons in the manner of classical neurotransmission but from serotonergic varacosities into the extra neuronal space. From here it is free to diffuse over a relatively large region of space (>20µm) and activate 5-HT receptors located on the dendrites, cell bodies and presynaptic terminals of adjacent neurons. Serotonergic action is terminated primarily via uptake of 5-HT from the synapse. This is through the specific monoamine transporter for 5-HT, 5-HT reuptake transporter, on the presynaptic neuron. The pharmacology of 5-HT is extremely complex, with its actions being mediated by a large and diverse range of 5-HT receptors. |
| Storage: | Store at 4C. |
| Purity: | Tissue culture supernatant |
| Isotype: | IgG1 kappa |
| Host Name: | Mouse |
| Buffer: | BSA, 10mM PBS. pH 7.4 |
| Application Summary: | Immunohistochemistry-Paraffin |
| Species Summary: | Hu, |
| Alternate Names: | anti-5HT antibody |
| Package Size: | 1 ml |
| Preservative: | Sodium Azide |
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