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| Catalog Code: | NB120-15194 |
| Product Name: | Cullin 2 Antibody |
| Product Description: | Rabbit Polyclonal anti-Cullin 2 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Synthetic peptide (Human) (C terminal). |
| Cross Reactivity: | Cross-reacts with Human and Mouse.Not yet tested in other species. |
| Packaging: | 7 ml Immunogen affinity purified Rabbit IgG |
| Uses: | IHC-P: Ready diluted. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Nuclear |
| Background: | Cullin 2 is a member of the family of human Cullin genes (CUL1, 2, 3, 4a, 4b and 5) homologous to the S. cerevisiae cdc53 gene. It is a component of E3 ubiquitin ligase complexes, including the inactive transcriptional elongation complex SIII, which mediates the ubiquitination of hypoxia-inducible factor (HIF). SIII is formed by three subunits: Elongin C, Elongin B and VHL. Cullin 2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | BSA, 10mM PBS. pH 7.4 |
| Application Summary: | immunohistochemistry-P |
| Species Summary: | Hu, Mu, |
| Alternate Names: | anti-CUL 2 antibody, anti-cul2 antibody, anti-MGC131970 antibody |
| Package Size: | 7 ml |
| Preservative: | Sodium Azide |
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more information: | company product webpage |