| CatalogCode: | NB120-15166 |
| ProductName: | PAX5 Antibody |
| Product Description: | Rabbit Polyclonal anti-PAX5 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) (Human) (C terminal). |
| CrossReactivity: | Cross-reacts with Human, Mouse and Rat.Not yet tested in other species. |
| Packaging: | 7 ml Immunogen affinity purified Rabbit IgG. |
| Uses: | IHC-P: Use at an assay dependent dilution. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Nuclear |
| Control: | Tonsil. |
| Background: | The PAX5 gene is a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. The PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. The PAX5 gene encodes the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis, therefore, PAX5 gene product may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis. PAX5 expression is not only continuously required for B cell lineage commitment during early B cell development but also for B lineage maintenance. PAX5 is found in most cases of mature and precursor B cell non-Hodgkin lymphomas/leukemias. Pax-5 is not detected in Multiple myeloma and solitary plasmacytoma cell lymphomas do express Pax5 except for those with terminal B cell differentiation. T cell neoplasms do not stain with anti-Pax5; however there is a strong association with CD20 expression. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS, BSA |
| ListPrice: | 285 |
| AppSummary: | IHC-P |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-B cell lineage specific activator protein antibody, anti-B cell specific transcription factor antibody, anti-BSAP antibody, anti-Paired box 5 antibody, anti-Paired box gene 5 (B cell lineage specific activator protein) antibody, anti-Paired box gene 5 antibody, anti-Paired box homeotic gene 5 antibody, anti-Paired box protein Pax 5 antibody, anti-PAX 5 antibody, anti-Transcription factor PAX 5 antibody |
| ProteinTarget: | PAX5, prediluted |
| PackageSize: | 7 ml |
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