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| Catalog Code: | NB120-15151 |
| Product Name: | alpha 1 Catenin Antibody |
| Product Description: | Rabbit Polyclonal anti-alpha 1 Catenin |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Concentration: | 0.2 mg/ml |
| Immunogen: | Synthetic peptide (Human) (C terminal). |
| Cross Reactivity: | Cross-reacts with Human, Mouse and Xenopus laevis. Not yet tested in other species. |
| Packaging: | 1 ml Immunogen affinity purified Rabbit IgG. |
| Uses: | IHC-P: Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cell Membrane and Cytoplasmic |
| Background: | The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kDa) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 10mM PBS, BSA. pH 7.4 |
| Application Summary: | immunohistochemistry-P |
| Species Summary: | Hu, Mu, Xp, |
| Alternate Names: | anti-alpha catenin antibody, anti-Alpha E Catenin antibody, anti-alphaE catenin antibody, anti-Cadherin associated protein 102kDa antibody, anti-Cadherin associated protein antibody, anti-CAP 102 antibody, anti-CAP102 antibody, anti-Catenin (cadherin associated protein) alpha 1 102kDa antibody, anti-Catenin alpha 1 antibody, anti-CTNNA 1 antibody, anti-CTNNA1 antibody, anti-FLJ36832 antibody, anti-NY REN 13 antigen antibody |
| Package Size: | 1 ml |
| Preservative: | Sodium Azide |
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more information: | company product webpage |
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