| CatalogCode: | NB120-15135 |
| ProductName: | ErbB 3 Antibody |
| Product Description: | Rabbit Polyclonal anti-ErbB 3 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) (Human) (N terminal). |
| CrossReactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.5 ml Immunogen affinity purified Rabbit IgG. |
| Uses: | IHC-P: Use at a dilution of 1/30 for 10 min at RT.IP: Use at an assay dependent dilution. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Type I membrane protein and Secreted |
| Control: | Skeletal muscle.Breast, stomach, pancreas, and colon tumours. |
| Background: | The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | BSA, 10mM PBS. pH 7.4 |
| ListPrice: | 330 |
| AppSummary: | IHC-P, IP |
| SpeciesSummary: | Hu |
| ALTnames: | anti-c erbB 3 antibody, anti-c erbB3 antibody, anti-ERBB3 antibody, anti-ERBB3 protein antibody, anti-erbB3 S antibody, anti-Glial growth factor receptor antibody, anti-HER 3 antibody, anti-HER3 antibody, anti-MDA BF 1 antibody, anti-MGC88033 antibody, anti-p180 ErbB3 antibody, anti-p45 sErbB3 antibody, anti-p85 sErbB3 antibody, anti-Receptor tyrosine protein kinase erbB 3 antibody, anti-Receptor tyrosine protein kinase erbB3 antibody, anti-Tyrosine kinase type cell surface receptor HER3 antibody, anti-v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 antibody, anti-v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody, anti-v erb b2 erythroblastic leukemia viral oncogene homolog 3 antibody |
| ProteinTarget: | ErbB 3 |
| PackageSize: | 0.5 ml |
|