| CatalogCode: | NB120-15130 |
| ProductName: | c-Abl Antibody |
| Product Description: | Rabbit Polyclonal anti-c-Abl |
| Clonality: | Polyclonal |
| Immunogen: | A synthetic peptide from the sequence adjacent to protein tyrosine kinase domain of human c-Abl. |
| CrossReactivity: | Cross-reacts with Human and Mouse.Not yet tested in other species. |
| Packaging: | 0.5 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | IHC-P: Use for 10 min at RT. Boil tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cytoplasmic and Nuclear |
| Control: | Placenta. |
| Background: | The c-Abl proto oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c-Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) As the result of the fusion of c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | BSA, 10mM PBS. pH 7.4 |
| ListPrice: | 285 |
| AppSummary: | IHC-P, IP, WB |
| SpeciesSummary: | Hu, Mu |
| ALTnames: | anti-Abelson Murine Leukemia Viral Oncogene Homolog 1 antibody, anti-Abelson murine leukemia viral v abl oncogene homolog 1 antibody, anti-Abl 1 antibody, anti-ABL antibody, anti-Abl protein antibody, anti-Abl1 antibody, anti-Bcr/c abl oncogene protein antibody, anti-JTK 7 antibody, anti-JTK7 antibody, anti-p150 antibody, anti-Proto oncogene tyrosine protein kinase ABL1 antibody, anti-Transformation gene oncogene ABL antibody, anti-v abl Abelson murine leukemia viral oncogene homolog 1 antibody, anti-v abl antibody |
| ProteinTarget: | c-Abl |
| PackageSize: | 0.5 ml |
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