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| Catalog Code: | NB120-14297 |
| Product Name: | ENSA Antibody |
| Product Description: | Chicken Polyclonal anti-ENSA |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Concentration: | 1 mg/ml |
| Immunogen: | Full length protein: corresponding to amino acids 1-121 of Human ENSA. |
| Cross Reactivity: | Cross-reacts with Human, Mouse, Rat and Bovine. Not yet tested in other species. |
| Packaging: | 0.05 mg Immunogen affinity purified Chicken IgY |
| Uses: | IHC: Use at a dilution of 1/200. WB: Use at a dilution of 1/1000 - 1/2000. Predicted molecular weight: 15 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cytoplasmic |
| Background: | Alpha endosulfine is expressed in a wide range of tissues including muscle, brain, and endocrine tissues. The recombinant protein inhibits binding of labeled glibenclamide to beta cell membranes. It also inhibits cloned K(ATP) channel currents and thereby stimulates insulin secretion. It was proposed that endosulfine is an endogenous regulator of the K(ATP) channel, which has a key role in the control of insulin release and, more generally, couples cell metabolism to electrical activity. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgY |
| Host Name: | Chicken |
| Buffer: | PBS |
| Application Summary: | immunohistochemistry, Western Blot |
| Species Summary: | Bv, Hu, Mu, Rt, |
| Alternate Names: | anti-Alpha endosulfine antibody, anti-ARPP 19e antibody, anti-Endosulfine alpha antibody,anti-MGC4319 antibody , anti-MGC78563 antibody, anti-MGC8394 antibody |
| Package Size: | 0.05 mg |
| Preservative: | None |
| Notes Main: | During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 uL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap. |
| General References: | General / background references:Heron L et al. Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: molecular cloning, expression and biological properties. Proc Natl Acad Sci U S A 95:8387-91 (1998). |
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